Job Reference
504_25_LS_CB_R2
Position
Computational Biology Systems Researcher (R2) – codesign activities (LS & CS)
Closing Date
Thursday, 18 September, 2025
Reference:
504_25_LS_CB_R2
Job title:
Computational Biology Systems Researcher (R2) – codesign activities (LS & CS)
About BSC
The Barcelona Supercomputing Center - Centro Nacional de Supercomputación (BSC-CNS) is the leading supercomputing center in Spain. It houses MareNostrum, one of the most powerful supercomputers in Europe, was a founding and hosting member of the former European HPC infrastructure PRACE (Partnership for Advanced Computing in Europe), and is now hosting entity for EuroHPC JU, the Joint Undertaking that leads large-scale investments and HPC provision in Europe. The mission of BSC is to research, develop and manage information technologies in order to facilitate scientific progress. BSC combines HPC service provision and R&D into both computer and computational science (life, earth and engineering sciences) under one roof, and currently has over 1000 staff from 60 countries.
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We are particularly interested for this role in the strengths and lived experiences of women and underrepresented groups to help us avoid perpetuating biases and oversights in science and IT research. In instances of equal merit, the incorporation of the under-represented sex will be favoured.
We promote Equity, Diversity and Inclusion, fostering an environment where each and every one of us is appreciated for who we are, regardless of our differences.
If you consider that you do not meet all the requirements, we encourage you to continue applying for the job offer. We value diversity of experiences and skills, and you could bring unique perspectives to our team.
Context And Mission
The Laboratory of Open Computer Architecture (LOCA) at Barcelona Supercomputing Center aims to break through traditional disciplinary silos and lead the research and development of European open software and hardware stacks based on the RISC-V Instruction Set Architecture for Exascale and beyond. This will be done with BSC's scientific departments to produce highly optimized grand challenge scientific applications in climate modelling, personalized medicine and energy. LOCA spans topics ranging from Computer Architecture to System Software to Applications, in both traditional HPC and emerging High-Performance Data Analytics (HPDA) and is working towards EU autonomy in HPC technologies. BSC is looking for one domain expert for each of the centre's application departments (Earth Science, Life and Engineering Sciences) to contribute to this aim.
In the Life Sciences area, we are looking for a Researcher to work in the computational systems biology approaches to simulate biological networks at different time-scales (Ponce-de-Leon et al., In particular, we are interested in the development of new approaches to the simulation of different molecular networks and of different type of cells, with emphasis on genome-scale metabolic models, Boolean regulatory networks and agent-based models, as well as the integrations of omic information to validate model predictions. These multi-scale models simulations should be able to be adapted to parallel environments to be deployed to HPC platforms at the BSC and at other HPC centres in Europe.
The Researcher will work in the construction and simulation of context-specific cell-decisions multi-scale models for predictive analysis. The specific tasks involve the development and application of bioinformatics and computational methods to integrate (epi)genomic, proteomic and transcriptomic data into predictive models, with an emphasis on context-specific intracellular models that combine metabolic and signalling pathways and that could be integrated in multi-scale models for personalised medicine.
The candidate will be working in close collaboration with all the different groups and departments to co-design these novels tools to new computer architectures (Kreuzer et al., 2021) in the context of the BSC's Severo Ochoa award for the period, which aims to boost BSC capacities to codesign hardware and software, maximise internal and external synergies, expand international leadership, provide best-practice career development with strong gender actions, and enhance societal engagement and technology