06 ago | Institut de Recerca contra la Leucèmia Josep Carreras | Municipio de Badalona
06 ago
The Josep Carreras Leukaemia Research Institute (IJC) is a comprehensive cancer research center dedicated to conducting research and driving innovation in the epidemiological, preventive, clinical, translational, and basic aspects of leukaemia and other hematologic malignancies, with the final aim of finding a cure for these diseases. Created in 2010, it has experienced exponential growth.
The IJC is part of the network of Excellence Research Centers of Catalonia (CERCA) and was accredited as a Severo Ochoa Center of Excellence by the Ministry of Science, Innovation, and Universities in 2024. Since 2018, the Institute has also been accredited by the Scientific Foundation of the Spanish Association Against Cancer (FCAECC). Additionally, IJC is one of the centers integrated into the Institut de Recerca Germans Trias i Pujol (IGTP) accreditation as an Accredited Health Research Institute (IIS ) by the Carlos III Health Institute (ISCIII ).
The IJC's main headquarters is located within the Can Ruti Biomedical Campus, alongside other leading biomedical institutions, providing access to cutting-edge scientific and technological facilities and community services. The IJC has six locations integrated into reference hospitals :
Hospital Germans Trias i Pujol, Hospital Clínic, Hospital Sant Pau, Hospital Josep Trueta, Hospital del Mar, and Hospital San Joan de Déu. This facilitates close collaboration between basic and clinical researchers, fostering translational research that integrates basic science with clinical practice.
We are seeking a Predoctoral Researcher for the T-ALL Team/ALL Group, under the supervision of Dra. Eulàlia Genescà.
RESEARCH DESCRIPTION
The biological landscape of T-ALL has been extensively mapped. Genomic analyses have identified over 100 genetic alterations, with ten key recurrently mutated pathways including transcriptional regulation (91%), cell cycle and tumor suppression (84%), NOTCH1 signaling (79%), epigenetic regulation (68%), PI3K-AKT-mTOR (29%), JAK/STAT (25%), RAS (14%), ribosome function (13%), ubiquitination (9%), and RNA processing (9%). Despite this, predicting therapeutic response based solely on genomics remains unreliable due to the complex interaction of cellular pathways in vivo. Functional precision medicine offers a promising alternative.
The ALL-TARGET project builds on this foundation, proposing a pragmatic, randomized controlled trial comparing standard treatment with three targeted therapeutic options (TTOs) based on repositioned drugs. A key component is a precision medicine arm where treatment is guided by a functional drug testing assay, integrating phenotypic and genomic profiling with ex vivo sensitivity results.
MAIN RESPONSABILITIES
* Drug screening on cell lines and primary samples.
* Identify signaling pathways and biomarkers of drug response.
* Establish genetic-phenotypic correlations to drug response.
* Validate results in an in vivo model.
WHAT WE NEED
* Experience in drug screening and cell culture.
* Motivation in biomedical research, proactivity, analytical skills, team spirit.
* High collaborative and communication skills.
* Proficiency in English (spoken and written) is required.
* Good management skills in R are a plus.
WHAT WE OFFER
* Full-time contract.
* Part of a young, collaborative, international environment with cutting-edge technologies and interdisciplinary teams including experts in medicine, genomics, and bioinformatics.
* The stimulating environment of the Barcelona metropolitan area.
* Opportunities for professional growth in an advanced research setting.
DEADLINE
Application deadline details to be specified.
WHO WE ARE
What makes us different? The Josep Carreras Institute aims to conduct innovative research in leukemia and hematologic malignancies, with the ultimate goal of finding a cure. Our vision is to be a world-class research multicampus contributing to improved patient outcomes through innovation, sustainability, social responsibility, talent, and professionalism.
HR Excellence:
In 2019, IJC received the "Human Resources Excellence in Research Award" from the European Commission, recognizing our policies aligned with the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers.
The original ad can be found on Kit Empleo:
#J-18808-Ljbffr