Organisation/Company Centre for Genomic Regulation Research Field Biological sciences » Other Researcher Profile First Stage Researcher (R1) Recognised Researcher (R2) Positions Postdoc Positions Country Spain Application Deadline 31 May 2025 - 23:59 (Europe/Madrid) Type of Contract Other Type of Contract Extra Information Open-ended Job Status Full-time Hours Per Week 40 Offer Starting Date 1 Apr 2025 Is the job funded through the EU Research Framework Programme? Horizon Europe Reference Number 101157669 Is the Job related to staff position within a Research Infrastructure? No
Offer Description
The Institute
The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed by an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by high-end and innovative technologies.
We are seeking a motivated postdoctoral scientist interested in dissecting genome regulatory mechanisms underlying human diabetes. The successful applicant will develop cell-based model systems such as human stem cell-derived beta cells, using single cell genomic read-outs, and will explore poorly understood genome regulatory mechanisms. The work will be performed within a multidisciplinary lab located in the CRG.
About the lab
The Regulatory Genomics and Diabetes lab aims to uncover genetic mechanisms causing diabetes mellitus, and to develop therapeutic avenues. The group is particularly interested in understanding how genomic information is used to direct cell-specific gene expression, and to pinpoint gene regulatory defects underlying human disease.
The team brings together diverse expertise, ranging from work with mutant stem cell-derived beta cell organoids, engineered mouse models, single cell epigenomics, large-scale genetic screens, statistical genetics, and the integration of genetic and regulatory data. This multidisciplinary approach gives us unique opportunities to engage in collaborative projects that combine experimental and computational methods. The lab encourages wet lab scientists to engage in their own data analysis and provides a supportive environment to this end. The group is funded by European Research Council, the Spanish Ministry of Science and Innovation, Generalitat de Catalunya, an AXA chair, European Foundation for the Study of Diabetes, the Marie Skłodowska-Curie Actions program, and a CIBERDEM diabetes network. The lab forms part of international consortia focused on advancing research in regulatory genomics, single cell genomics, and human genetics.
Recent studies from the lab include:
* A lineage-specific gene transcription and splicing hierarchy that is disrupted in type 2 diabetes (In review)
* Large-scale discovery of molecular targets for precision treatment of HNF1A-deficient diabetes (In review).
* Transcription regulation by long non-coding RNAs and their disease relevance (Nat Rev Mol Cell Biol, 2024).
* HASTER lncRNA promoter is a cis-acting transcriptional stabilizer of HNF1A (Nat Cell Biol 2022).
* Pancreas agenesis mutations disrupt a lead enhancer controlling a developmental enhancer cluster (Dev Cell, 2022).
* Human pancreatic islet 3D chromatin architecture provides insights into the genetics of type 2 diabetes (Nat Genet 2019).
Whom would we like to hire?
Professional experience
Must Have
* Solid track record in molecular and cell biology and expertise in one of the following fields: genome/epigenome editing tecnologies, single cell genomic methods, or in development of protocols with this technology
* Expertise in next generation sequence analysis
* You have a publication track record in these areas with a leading authorship role
Education and training
* A PhD in a relevant field
Languages
* You are proficient in English
Technical skills
* You have advanced MS Office skills
Competences
* Highly developed organizational and communication skills
* Ability to work in a team
The Offer – Working Conditions
* Contract duration: Contract for Technical and Scientific Activities – estimated duration of 2 years, with the possibility of renewal .
* Estimated annual gross salary: Salary is commensurate with qualifications and consistent with our pay scales.
We provide a highly stimulating environment with state-of-the-art infrastructures, and unique professional career development opportunities. To check out our training and development portfolio, please visit our website in the training section .
We offer and promote a diverse and inclusive environment and welcomes applicants regardless of age, disability, gender, nationality, ethnicity, religion, sexual orientation or gender identity.
The CRG is committed to reconcile a work and family life of its employees and are offering extended vacation period and the possibility to benefit from flexible working hours.
Application Procedure
All applications must include:
* A motivation letter addressed to Dr Jorge Ferrer
* Pre-selection: The pre-selection process will be based on qualifications and expertise reflected on the candidates CVS. It will be merit-based.
* Interview: Preselected candidates will be interviewed by the Hiring Manager of the position and a selection panel if required.
* Offer Letter: Once the successful candidate is identified the People department will send a Job Offer, specifying the start day, salary, working conditions, among other important details.
Deadline: The position will be opened until it is covered.
This contract has received funding from the European Union's Horizon Europe under the grant agreement No [101157669]"
Suggestions: The CRG believes in ongoing improvement and promotes a culture of feedback. This is one of the reasons we have in place, at your disposal as a candidate, a mechanism to gather your suggestions/complaints concerning your candidate experience in our recruitment processes. Your feedback really matters to us in our aim at creating a positive candidate journey. You can make a difference and help us improve by letting us know your suggestions through the following form. https://recruitment.crg.eu/webforms/recruitment-contact-form-suggestionscomplaints
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