Job Reference & Title
Reference: 138_26_LS_CB_R2
Job title: Computational Biology Systems Researcher (R2)
About BSC
The Barcelona Supercomputing Center - Centro Nacional de Supercomputación (BSC-CNS) is the leading supercomputing center in Spain. It houses MareNostrum, one of the most powerful supercomputers in Europe, was a founding and hosting member of the former European HPC infrastructure PRACE (Partnership for Advanced Computing in Europe), and is now hosting entity for EuroHPC JU, the Joint Undertaking that leads large‑scale investments and HPC provision in Europe. The mission of BSC is to research, develop and manage information technologies in order to facilitate scientific progress. BSC combines HPC service provision and R&D into both computer and computational science (life, earth and engineering sciences) under one roof, and currently has over 1000 staff from 60 countries.
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We are particularly interested for this role in the strengths and lived experiences of women and under‑represented groups to help us avoid perpetuating biases and oversights in science and IT research. In instances of equal merit, the incorporation of the under‑represented sex will be favoured.
We promote Equity, Diversity and Inclusion, fostering an environment where each and every one of us is appreciated for who we are, regardless of our differences.
If you consider that you do not meet all the requirements, we encourage you to continue applying for the job offer. We value diversity of experiences and skills, and you could bring unique perspectives to our team.
Context & Mission
In the Life Sciences area, we are looking for a Researcher to work in the computational systems biology approaches to simulate biological models at different time‑scales in the context of the development of the PhysiCell/PhysiBoSS modelling systems (Ponce‑de‑Leon et al., 2023). We focus on the development of new approaches to the simulation of different molecular networks and of different types of cells, with emphasis on genome‑scale metabolic models, Boolean regulatory models and physical agent‑based models, as well as the integrations of omic information to validate model predictions in HPC environments at the BSC and at other HPC centres in Europe. The Researcher will work in the construction and simulation of context‑specific cell‑decisions multi‑scale models for predictive analysis in projects developed in collaboration with experimental groups. The tasks involve the development and application of bioinformatics and computational methods to integrate (epi)genomic, proteomic and transcriptomic data into predictive models powered by AI and agentic AI approaches, with an emphasis on context‑specific intracellular models for personalised medicine.
The candidate will be working in close collaboration with all the different groups and departments in the context of the BSC’s Severo Ochoa which aims to boost BSC capacities to codesign hardware and software.
Key Duties
* Implement efficient tools to simulate biological processes at different time scales through the integration of different modelling approaches (e.g. kinetic modelling, agent‑based modelling, constraint‑based modelling).
* Integrate multi‑omics data in the model and identify actionable patient‑specific targets of therapeutic interest.
* Collaborate with experimental groups, particularly those working in organoids, in the combination of modelling and experimental validation.
* Design, implement and deploy workflows that use agentic AI to accelerate the construction, prototyping, simulation and analyses of the multiscale models.
* Collaborate in the preparation and presentation of scientific projects.
* Follow the progress of PhD and MSc students of the department.
* Co‑organise sessions to disseminate the knowledge, progress, and projects of the LS department, in the shape of workshops and/or seminars.
Qualifications Education
PhD in Computer Science, Bioinformatics, Biology or similar topic, with strong background on computational biology.
Essential Knowledge and Professional Experience
* Proved experience on bioinformatics and computational biology.
* Strong background on computer simulation of biological processes (constraint‑based, Boolean, kinetic or agent‑based modelling).
* Strong programming skills, in particular on C++ and Python language.
* Administration level in Linux/Unix systems.
* Experience in HPC.
Additional Knowledge and Professional Experience
* Good communication skills (verbal and written) in English, and ability to effectively communicate technical concepts to non‑experts.
Competences
* Proactive and able to take the initiative when needed.
* Creative thinking.
* Operate independently but also being part of a collaborative team.
Conditions
The position will be located at BSC within the Life Sciences Department.
We offer a full‑time contract (37.5h/week), a good working environment, a highly stimulating environment with state‑of‑the‑art infrastructure, flexible working hours, extensive training plan, restaurant tickets, private health insurance, support to the relocation procedures.
Duration: Open‑ended contract due to technical and scientific activities linked to the project and budget duration.
Holidays: 22 days of holidays + 6 personal days + 24th and 31st of December per our collective agreement.
Salary: we offer a competitive salary commensurate with the qualifications and experience of the candidate and according to the cost of living in Barcelona.
Starting date: 01/05/2026 or later.
Application Procedure
All applications must be submitted via the BSC website and contain:
* A full CV in English including contact details.
* A cover/motivation letter with a statement of interest in English, clearly specifying for which specific area and topics the applicant wishes to be considered. Additionally, two references for further contacts must be included. Applications without this document will not be considered.
The selection will be carried out through a competitive examination system (\"Concurso‑Oposición\"). The recruitment process consists of two phases: Curriculum Analysis (40 points) and Interview phase (60 points). A minimum of 30 points out of 60 must be obtained to be eligible for the position.
Final decision will be made by a recruitment panel composed of at least three people, ensuring at least 25% representation of women, with a gender‑balanced panel and personality questionnaire and technical exercise as part of the process.
Equal Opportunity Statement
BSC‑CNS is an equal opportunity employer committed to diversity and inclusion. We are pleased to consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability or any other basis protected by applicable state or local law.
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