The Cent re for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed by an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by high-end and innovative technologies.
Th e successful candidate is a postdoctoral researcher and will be expected to study the process of unconventional secretion of proteins in mammalian tissue culture cells. The candidate should have a solid background in cell biology, with a special interest in trafficking and quality control of proteins for secretion outside of the cell.
About the lab
The Intracellular compartmentation lab studies different aspects of protein secretion. Protein secretion is an old problem of fundamental interest in cell biology. While over the last decades a lot of progress has been made in understanding protein secretion, several questions remain unsolved.
The lab aims to understand different aspects of this. On the one hand they focus on the transport and secretion of large, complex cargoes (like collagens and mucins) that do not fit the conventional secretory pathway. On the other hand, they study the process whereby cytoplasmic, signal sequence lacking proteins are secreted from cells upon certain stimuli (known as unconventional protein secretion). Research performed in the lab has implicated a yeast protein called Grh1 to be central in the unconventional secretion of a number of cytoplasmic proteins. However, the exact mechanism by which cargoes are selected and how Grh1 contributes to their secretion remains unclear to date.
The lab is currently investigating the role of mammalian Grh1 (GRASP) proteins in the secretion of selected cytoplasmic cargoes, such as ACBP.
Whom would we like to hire? Professional experience Must Have
* You have a comprehensive understanding and proven ability to modern approaches of molecular cell biology
* You have experience in genetic engineering of metazoans (e.G. Cripsr-Cas9 editing of tissue culture cell lines)
* You have experience with imaging techniques, preferably super resolution microscopy
* You authored p ublications in peer reviewed journals to demonstrate expertise in the procedures mentioned above
Desirable but not required / Nice to have
* You have experience with advanced bioinformatic tools ( e.G. Python/R, omics data analysis)
Education and training
* A Ph.D. in a relevant field of study and/or candidates with no more than one year of postdoctoral experience are also encouraged to apply.
* Demonstrated expertise through peer-reviewed publications in reputable journals is essential.
Languages
You are fluent in English (written and spoken)
Technical skills
* Modern approaches in molecular cell biology and super resolution microscopy
Competences
* A demonstrated ability to organize and contribute original ideas to scientific research
* Excellent scientific communication skills ( demonstrated abilities in manuscript and grant writing, conference presentations, etc.)
* Strong organizational skills
The Offer – Working Conditions
Contract duration: Technical and scientific activities contract linked to the project duration (estimated until 31/8/2027)
Estimated annual gross salary: Salary is commensurate with qualifications and consistent with our pay scales.
Target start date: As soon as possible
We provide a highly stimulating environment with state-of-the-art infrastructures, and unique professional career development opportunities. To check out our training and development portfolio, please visit our website in the training section.
We offer and promote a diverse and inclusive environment and welcomes applicants regardless of age, disability, gender, nationality, ethnicity, religion, sexual orientation or gender identity.
The CRG is committed to reconcile a work and family life of its employees and are offering extended vacation period and the possibility to benefit from flexible working hours.
Application Procedure
All applications must include:
A motivation letter addressed to Dr Vivek Malhotra
Contact details of two referees.
All applications must be addressed to Dr. Vivek Malhotra and be submitted online through the "Apply" button below.
Selection Process
Pre-selection: The pre-selection process will be based on qualifications and expertise reflected on the candidates CVS. It will be merit-based.
Interview: Preselected candidates will be interviewed by the Hiring Manager of the position and a selection panel if required.
Offer Letter: Once the successful candidate is identified the People department will send a Job Offer, specifying the start day, salary, working conditions, among other important details.
Deadline
Please submit your application by October 31 st, 2025
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