The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed by an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by high-end and innovative technologies.
We look for a highly motivated young researcher to work on projects related to cancer evolution from a transcriptomic perspective. The candidate will evaluate transcriptomic cancer signatures of gene expression and alternative splicing across species. For this, the candidate will process bulk and single-cell data from multiple species and tissues and will derive and validate various cancer and age-related signatures. In a second step, genome adaptations in protein-coding sequences and regulatory regions behind those transcriptomic adaptations will be identified.
About the lab
The Irimia lab is an international and multi-disciplinary team dually affiliated with UPF and CRG. It focuses primarily on elucidating the role of alternative splicing in vertebrate development and adult function, generally applying explicit evolutionary perspectives. Part of our work focuses on microexons in the nervous system and in endocrine pancreas, a splicing program that we have originally discovered and to which we have made key contributions. In our lab, we combine computational approaches (comparative bulk and single-cell transcriptomics and functional genomics) with experiments using in vitro and in vivo systems. In addition, we have recently started a strong collaboration with the BIMSB-MDC in Berlin, with the overarching goal of advancing single-cell transcriptomics with isoform resolution.
Professional experience
* You have some experience in cancer evolutionary analyses
* You have proven experience in programming
* You are fluent in English
Education and training
* You hold a MSc in biological sciences
Languages
* You are proficient in English
Technical skills
* You have programming skills
Competences
* Highly developed organizational skills
The Offer – Working Conditions
* Contract duration: temporary position, 3 months
* Estimated annual gross salary: Salary is commensurate with qualifications and consistent with our pay scales
We provide a highly stimulating environment with state-of-the-art infrastructures, and unique professional career development opportunities.
We offer and promote a diverse and inclusive environment and welcomes applicants regardless of age, disability, gender, nationality, ethnicity, religion, sexual orientation or gender identity.
The CRG is committed to reconcile a work and family life of its employees and are offering extended vacation period and the possibility to benefit from flexible working hours.
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