Context And Mission
In the Life Sciences area, we are looking for a Researcher to work in the computational systems biology approaches to simulate biological models at different time-scales in the context oft the development of the PhysiCell/PhysiBoSS modelling systems(Ponce-de-Leon et al., 2023). In particular, we are interested in the development of new approaches to the simulation of different molecular networks and of different type of cells, with emphasis on genome-scale metabolic models, Boolean regulatory models and physical agent-based models, as well as the integrations of omic information to validate model predictions and developed in the context of the HPC environments at the BSC and at other HPC centres in Europe.
The Researcher will work in the construction and simulation of context-specific cell-decisions multi-scale models for predictive analysis in projects developed in collaboration with experimental groups. The specific tasks involve the development and application of bioinformatics and computational methods to integrate (epi)genomic, proteomic and transcriptomic data into predictive models powered byAI and agentic AI approaches, with an emphasis on context-specific intracellular models for personalised medicine.
The candidate will be working in close collaboration with all the different groups and departments in the context of the BSC’s Severo Ochoa which aims to boost BSC capacities to codesign hardware and software.
Key Duties
* Implement efficient tools to simulate biological processes at different time scales through the integration of different modelling approaches kinetic modelling, agent-based modelling, constraint-based modelling).
* Integrate multi-omics data in the model and identify actionable patient-specific targets of therapeutic interest.
* Collaborate with experimental groups, particularly those working in organoids, in the combination of modelling and experimental validation.
* Design, implement and deploy workflows that use agentic AI to accelerate the the construction, prototyping, simulation and analyses of the multiscale models.
* Collaborate in the preparation and presentation of scientific projects.
* Follow the progress of PhD and MSc students of the department.
* Co-organize sessions to disseminate the knowledge, progress, and projects of the LS department, in the shape of workshops and/or seminars.
Requirements
* Education
o PhD in Computer Science, Bioinformatics, Biology or similar topic, with strong background on computational biology.
* Essential Knowledge and Professional Experience
o Proved experience on bioinformatics and computational biology.
o Strong background on computer simulation of biological processes (constraint-based, Boolean, kinetic or agent-based modelling).
o Strong programming skills, in particular on C++ and Python language.
o Administration level in Linux/Unix systems.
o Experience in HPC.
* Additional Knowledge and Professional Experience
o Good communication skills (verbal and written) in English, and ability to effectively communicate technical concepts to non-experts.
* Competences
o Proactive and able to take the initiative when needed.
o Creative thinking.
o Operate independently but also being part of a collaborative team.
Conditions
* The position will be located at BSC within the Life Sciences Department
* We offer a full-time contract a good working environment, a highly stimulating environment with state-of-the-art infrastructure, flexible working hours, extensive training plan, restaurant tickets, private health insurance, support to the relocation procedures
* Duration: Open-ended contract due to technical and scientific activities linked to the project and budget duration
* Holidays: 22 days of holidays + 6 personal days + 24th and 31st of December per our collective agreement
* Salary: we offer a competitive salary commensurate with the qualifications and experience of the candidate and according to the cost of living in Barcelona
* Starting date: 01/05/2026 or later