Would you like to help us make EURAXESS even better? Take this very quick user satisfaction survey - it won’t take more than 5 minutes!Department of Experimental and Health SciencesOrganisation/Company Universitat Pompeu Fabra Department Department of Experimental and Health Sciences Research Field Biological sciences Researcher Profile Recognised Researcher (R2) Positions Postdoc Positions Country Spain Application Deadline 30 Sep 2025 - 23:
59 (Europe/Madrid) Type of Contract To be defined Job Status Full-time Offer Starting Date 21 Jul 2025 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? NoOffer Description
We are seeking a highly motivated postdoctoral researcher to join an exciting international project investigating how alternative splicing, especially of microexons, influences the maturation of pancreatic islets.Despite major advances in stem cell-derived islet differentiation, achieving fully functionally mature beta cells in vitro remains a critical challenge. This project aims to uncover novel regulatory mechanisms that drive beta cell maturation, with the potential to improve diabetes therapies.As the lead scientist, you will apply single-cell long-read sequencing, CRISPR interference (CRISPRi), and small molecule modulation to dissect the molecular pathways underlying islet development.You will conduct and coordinate experimental work across two vibrant research environments:
the Irimia Lab at UPF-CRG in Barcelona and the Sander Lab at the MDC in Berlin.Where to apply
E-mail mirimia@gmail.comrequirements
Research Field Biological sciences Education Level PhD or equivalentSkills/Qualifications* Key responsibilities include:
- Differentiation of pancreatic islets from stem cells in vitro.- CRISPRi-based gene perturbation in islets.- Small molecule screening experiments.- In vivo transplantation of islets and functional assays.- Execution and, potentially, analysis of single-cell long-read sequencing.Additional Information
* What We Offer:
- Collaborative, interdisciplinary mentorship from two leading labs.- Access to state-of-the-art facilities and innovative technologies.- International exposure and training across two world-class institutions.- The opportunity to lead experimental directions in a high-impact research area.Selection processSend an email to Manuel Irimia (mirimia@gmail.com ) with your CV and motivation letter.
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