Research Trainee – Proteomics and Centrosome Biology
The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed of an interdisciplinary, motivated and creative scientific team supported by flexible administration and high‑end innovative technologies.
The Bettencourt‑Dias Laboratory at the CRG is seeking a motivated Research Trainee for a 3‑month period starting 15 July 2026. The trainee will investigate proteostatic networks that govern centrosome homeostasis in health and disease, providing hands‑on experience in mass‑spectrometry‑based proteomics applied to centrosome biology.
The trainee will develop and apply quantitative proteomics pipelines (SILAC pulse‑chase and DIA) to map the turnover of centrosomal proteins across the cell cycle, contribute to centrosome isolation via CAP‑ture‑based enrichment, and perform bioinformatic analyses to integrate proteomic datasets with imaging data.
About the lab
The Bettencourt‑Dias Laboratory investigates how centrioles and centrosomes are built, maintained, and eliminated, and how their deregulation drives cancer and ciliopathies. The group combines quantitative cell biology, super‑resolution microscopy, proteomics, and computational approaches. It is based at the Barcelona Biomedical Research Park (PRBB) and is part of the CRG’s Programme on Quantitative Cell Biology, led by Dr. Mónica Bettencourt‑Dias.
Qualifications
* Hands‑on experience with mass‑spectrometry‑based proteomics workflows, including data‑independent acquisition (DIA) and/or SILAC‑based approaches.
* Proficiency in proteomics data analysis software (e.g., Spectronaut, FragPipe, or Proteome Discoverer) and scripting languages (Python and/or R) for statistical analysis and pipeline development.
* Solid background in molecular and cellular biology and a genuine interest in cell biology and cancer research.
* Fluency in English.
Desirable but not required
* Familiarity with bioinformatics tools for interactome or network analysis (e.g., STRING, Cytoscape, AlphaFold).
Education and training
* BSc or MSc degree in Biochemistry, Biology, Bioinformatics, or a closely related field.
Languages
* Proficient in English (working language of the lab).
* Knowledge of Spanish or Catalan is helpful but not required.
Technical skills
* Experience with proteomics software (Spectronaut, FragPipe, and/or Proteome Discoverer) and Python and/or R for data analysis.
* Familiarity with Linux command‑line environments is an asset.
Competences
* Strong analytical and problem‑solving skills; meticulous attention to detail in data acquisition and analysis; ability to work independently and collaboratively in a dynamic, international team; proactive communication and genuine enthusiasm for cell biology research.
Offer – Working Conditions
* Contract duration: temporary contract from 15 July to 14 October 2026.
* Estimated annual gross salary: Salary is commensurate with qualifications and consistent with our pay scales.
* Target start date: 15 July 2026.
The CRG is committed to a work‑family balance and offers extended vacation periods and flexible working hours.
We offer and promote a diverse and inclusive environment and welcome applicants regardless of age, disability, gender, nationality, ethnicity, religion, sexual orientation, or gender identity.
All applicants must have a CV. The selection process will be based on qualifications and expertise, followed by interview and an offer letter if successful.
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