Overview The Laboratory of Open Computer Architecture (LOCA) at Barcelona Supercomputing Center aims to break through traditional disciplinary silos and lead the research and development of European open software and hardware stacks based on the RISC-V Instruction Set Architecture for Exascale and beyond. This will be done with BSC’s scientific departments to produce highly optimized grand challenge scientific applications in climate modelling, personalized medicine and energy. LOCA spans topics ranging from Computer Architecture to System Software to Applications, in both traditional HPC and emerging High-Performance Data Analytics (HPDA) and is working towards EU autonomy in HPC technologies. BSC is looking for one domain expert for each of the centre’s application departments (Earth Science, Life and Engineering Sciences) to contribute to this aim. In the Life Sciences area, we are looking for a Researcher to work in the computational systems biology approaches to simulate biological networks at different time-scales. In particular, we are interested in the development of new approaches to the simulation of different molecular networks and of different type of cells, with emphasis on genome-scale metabolic models, Boolean regulatory networks and agent-based models, as well as the integrations of omic information to validate model predictions. These multi-scale models simulations should be able to be adapted to parallel environments to be deployed to HPC platforms at the BSC and at other HPC centres in Europe. The Researcher will work in the construction and simulation of context-specific cell-decisions multi-scale models for predictive analysis, involving the development and application of bioinformatics and computational methods to integrate (epi)genomic, proteomic and transcriptomic data into predictive models, with an emphasis on context-specific intracellular models that combine metabolic and signalling pathways and that could be integrated in multi-scale models for personalised medicine. The candidate will be working in close collaboration with all the different groups and departments to co-design these novels tools to new computer architectures in the context of the BSC’s Severo Ochoa award for the period, which aims to boost BSC capacities to codesign hardware and software, maximise internal and external synergies, expand international leadership, provide best-practice career development with strong gender actions, and enhance societal engagement and technology #J-18808-Ljbffr