Role Overview
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Temporary Cellular Immunologist position within Almirall R&D’s Molecular and Cell Biology (MCB) team focused on advancing drug discovery in medical dermatology by developing physiologically relevant in vitro and ex vivo immunological models and assays. The role involves designing and implementing functional assay strategies to characterize biologics—especially cell‑depleting antibody modalities—and supporting target validation and mechanism‑of‑action studies in immune‑mediated skin diseases. The position is to replace a team member on parental leave.
Responsibilities
Collaborate with cross‑functional teams to identify and assess new therapeutic targets in in vitro and ex vivo models of dermatological indications with high unmet medical need.
Probe emerging methods for developing physiologically relevant cell and explant models of immune‑inflammatory and rare skin diseases, and characterize them using omics, spectral flow cytometry, and multiplexed immunoassays.
Design and develop in‑vitro assays to characterize the function and mechanism of action of biologics, with a key focus on cell‑depleting antibodies.
Drive the understanding of the therapeutic potential of biologics.
Propose innovative out‑of‑the‑box solutions, critically evaluate data, generate testable hypotheses, and solve challenging interdisciplinary problems.
Communicate effectively across several scientific disciplines.
Qualifications
PhD with 3+ years of experience in Immunology or Skin Biology (minimum requirement; additional experience valued).
Experience with primary immune cell isolation, culture, activation, and assays.
Background in human skin immunology; experience with skin cells or ex‑vivo skin biopsies is a plus.
Proficiency in immunophenotyping assays such as spectral flow cytometry and ELISA.
Experience with assays related to cell‑depleting functions of antibodies (ADCC/CDC/TCE or other modalities) highly desired.
Ability to propose innovative solutions, critically evaluate data, generate testable hypotheses, and solve interdisciplinary challenges. xpzdshu
Team player with strong communication skills across scientific disciplines.
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