Department of Biochemistry and Molecular Biology, Universidad Complutense
Deadline: 31 July 2026
57,812.34 euros gross per year according to MSCA Actions
We are seeking a postdoctoral researcher to join the Sheddome & Disease Lab led by Dr. Martin-de-Saavedra at the Universidad Complutense de Madrid (Spain), within the Department of Biochemistry and Molecular Biology. The candidate will apply for a Marie Skłodowska-Curie Actions (MSCA) Postdoctoral Fellowship. In the meantime, funding is available to support the selected candidate during the application and evaluation process. The Sheddome & Disease Lab is a dynamic and expanding research group dedicated to understanding how protein cleavage/shedding regulates neuronal function and contributes to neuropsychiatric disorders, including autism, schizophrenia, and epilepsy. By investigating how proteolytic processing of membrane proteins generates bioactive signaling molecules, the lab addresses fundamental and timely questions at the interface of molecular neuroscience and disease. The group employs a multidisciplinary and cutting‑edge approach, combining in‑vitro, in‑vivo models and human samples with advanced techniques in biochemistry, molecular and cell biology, imaging, proteomics, and bioinformatics. This integrated strategy enables the identification of novel mechanisms linking protein processing to synaptic function and neuronal communication. The lab offers a collaborative and supportive research environment, with a strong emphasis on scientific excellence, innovation, and career development. Postdoctoral researchers are encouraged to develop independent research ideas while benefiting from close mentorship, access to diverse methodologies, and opportunities for international collaboration. The overarching goal is to generate impactful discoveries that identify new therapeutic strategies for brain disorders. The successful candidate will investigate how the shedding of neurodevelopmental risk factors regulates neuronal function and contributes to neuropsychiatric disorders. The project is funded by the Spanish Research Agency (PID2024-156357OB-I00) and aims to uncover how proteolytic processing of membrane proteins influences synaptic communication and brain disease. The research will focus on identifying shedding‑regulated molecules and characterizing their impact on neuronal signaling and synaptic function, using a combination of in‑vitro and in‑vivo approaches, alongside biochemical, imaging, and omics‑based techniques.
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